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[] Increased activity of microglial cells (inflammatory processes, phagocytosis, disruption of the bloodbrain barrier and increased synthesis of oestrogen) was linked to increased ROS and unstable behaviours in mice

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This SORLA-ARR2 interaction, which is enhanced by PKC/-mediated phosphorylation of SORLA, leads to the ESCRT-0 complex-directed localization into late endosomes/lysosomes, ultimately resulting in the degradation of SORLA (illustrated in Fig

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Proper packaging (air-tight, opaque) preserves stability